Welcome to the #MEDSHED! Needing a brief, concise review of clinical pharmacotherapy and disease management? Direct links of reference to content discussed? Look no further than the #MEDSHED series based on infographics and carousel presentations!
🔮 Wernicke's Encephalopathy - #MEDSHED 👹
Pathophysiology
Severe, life-threatening complication from thiamine (Vitamin B1) deficienc Thiamine deficiency results in dysregulation of the Kreb’s cycle and pentose phosphate pathway Accumulation of toxic intermediate metabolites (lactate, glutamate), leading to cytotoxic edema Vasogenic edema develops from ATP depletion and disruption of blood-brain-barrier (BBB)
🤔 Clinical Presentation
Classical triad of Wernicke’s Encephalopathy (WE) altered mental status , ataxia, and oculomotor abnormalities only found in up to 33% of patients Alcoholism contributes to a large portion of WE cases, but can also be caused by malnutrition and digestive disorders WE can manifest into permanent, irreversible neurologic deficits (Korsakof Syndrome)
🌐 Thiamine Replacement
The mainstay of therapy for WE is thiamine replacement and should be given with a high degree of clinical suspicion Dosing Thiamine 200 - 500 mg IV piggyback over 30 minutes Varying dosing recommendations Consider high-dose thiamine TID for three days in acute WE treatment
🎥 For more #PHARMFAX in the drug bank, share the #MEDSHED with a friend, check out another post on my page, and I hope you learned something new.
Website: www.pharmwyze.com
Shop: www.pharmwyze.com/shop
Patreon: https://lnkd.in/gRuFrt6z
Paypal Donation: https://lnkd.in/g_F8suKh
Social Media: linktr.ee/pharmwyze
PHARMWYZE SITREP Newsletter: https://lnkd.in/gWriiDju
Not medical advice. Educational purposes only. No relationships to report.
#pharmacist #pharmwyze #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #thelab #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism #antipsychotics #drugs
Comments