Welcome to the #MEDSHED! Needing a brief, concise review of clinical pharmacotherapy and disease management? Direct links of reference to content discussed? Look no further than the #MEDSHED series based on infographics and carousel presentations!
🆎 Warfarin Reversal: Life-Threatening Bleed - #MEDSHED
What is Warfarin?
Anticoagulant; inhibits synthesis of the vitamin K dependent clotting factors (II, VII, IX, and X)
Supportive Care
Maintain and secure ABCs
Hemorrhage source control
Blood transfusion to maintain Hgb > 7 g/dL
Vitamin K (phytonadione)
Essential for hepatic synthesis of clotting factors
Dose: 10 mg IV piggyback
Caution: avoid rapid administration, associated with severe reactions
INR correction: ~ 6 hours
KCentra (4F-Prothombin Complex Concentrate) - give with Vitamin K
Contains clotting factors II, VII, IX, X, and protein C & S; heparin
INR correction: ~ 30 minutes
Onset of vitamin K maintains hemostasis as 4F-PCC effects diminish
Institution dosing may differ than package insert recommendations
Fresh Frozen Plasma (FFP) - give with Vitamin K
Contains clotting factors II, VII, IX, and X
Dose: Initial 4 units
Longer infusion time, slower correction of INR vs 4F-PCC; alternative
INR correction: similiar efficacy to 4F-PCC at 24 hours
Caution: fluid status, infusion rxn
Social Media Accounts: linktr.ee/pharmwyze
Website: www.pharmwyze.com
#emergencymedicine #criticalcare #medtwitter #pharmacy #nursing #medicine #studentpharmacist #foamed #emrx #studentpharmacist #pharmacy #nursingstudent #medicalschool #pharmacyschool #medicalstudent #meded #levels #medigram #pharmfax #pharmwyze #medshed #thelab #pharmacokinetics #pharmacodynamics #metabolism #absorption #cardiology #neurology #infection #nursing
Kommentare