Welcome to the #MEDSHED! Needing a brief, concise review of clinical pharmacotherapy and disease management? Direct links of reference to content discussed? Look no further than the #MEDSHED series based on infographics and carousel presentations!
đ« Naloxone: Opioid Reversal Agent - #MEDSHED
đ Naloxone is one of the few true reversal agents in medicine that I believe in. It is a pure opioid antagonist that displaces opioids from the receptor, resulting in reversal of toxicities and opioid effects.
đ± The dosing range is 0.4 to 2 mg for IV and IM administration, while IN requires an increased dose of equal to or greater than 2 mg for similiar effects as IV and/or IM.
âš With response to naloxone, patients should be started on a continuous infusion as most opioids have a duration that outlast naloxone (30 - 120 minutes). Patients may require repeat doses or continuous infusion if symptoms return.
đ It is best to keep the patent and medical team safe. Giving full dose reversal in a chronic opioid user can be dangerous as this may induce full blown acute withdrawal, making the patient combative, agitated, delirious, defecate, and/or severe HTN/tachycardia.
đč For these patients, consider diluting your dose and giving in aliquots of 0.1 - 0.2 mg/dose. Any patient with impending respiratory failure/arrest will need full dose naloxone.
đ„ For more #PHARMFAX in the drug bank, share the #MEDSHED with a friend, check out another post on my page, and I hope you learned something new.
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