Class Review: Cephalosporins - #MEDSHED

Welcome to the #MEDSHED! Needing a brief, concise review of clinical pharmacotherapy and disease management? Direct links of reference to content discussed? Look no further than the #MEDSHED series based on infographics and carousel presentations!

---

---

Class Review: Cephalosporins - #medshed

Cephalosporins are beta-lactams, which make them bactericidal via hydrolysis of the cell wall.

First -generation CEPH

Cephalexin (PO), Cefazolin (IV)

Gram (+): Streptococci species and methicillin-sensitive Staphylcoccus aureus (MSSA)

Gram (-): Enteric pathogens

Second-generation CEPH

Cefuroxime (IV/PO), Cefoxitin (IV), Cefotetan (IV)

Above + H. influenzae

Cefotixin and cefotetan contain anaerobe coverage

Third-generation CEPH

Cefdinir (PO), Cefpodoxime (PO), Ceftriaxone (IV), Ceftazadime (IV)

Above, excluding ceftazadime + N. meningitidis and Enterobacteriaceae

Ceftazadime is an anti-Pseudomonal, but does NOT contain gram (+) coverage

Fourth-generation CEPH

Cefepime (IV)

Above + Pseudomonas sp.

Cefepime poorly induces AmpC gene expression, exception to ineffective cephalosporins

Fifth-generation CEPH

Ceftaroline (IV)

Above with MRSA, without Pseudomonas

Ceftaroline is an anti-MRSA agent, does NOT have activity against Pseudomonas

Unlike other cephalosporins, contains activity against Enterococcus faecalis

For more #PHARMFAX deposits in your drug bank, share the #MEDSHED with a friend, check out another post on my page, and I hope you learned something new.

#pharmacy #medicine #pharmfax #pharmwyze #nursing #benzodiazepine #medshed #medigram #emergency #emergencymedicine #criticalcare

#infectiousdisease #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded 

References

Lin X, Kuck U. Appl Microbiol Biotechnol. 2022 Dec;106(24):8007-8020.